Circadian desynchronization

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Circadian desynchronization.

The suprachiasmatic nucleus (SCN) coordinates via multiple outputs physiological and behavioural circadian rhythms. The SCN is composed of a heterogeneous network of coupled oscillators that entrain to the daily light-dark cycles. Outside the physiological entrainment range, rich locomotor patterns of desynchronized rhythms are observed. Previous studies interpreted these results as the output ...

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Desynchronization of human circadian rhythms.

In man as well as in animals, diurnal rhythms are based on endogenous, periodic processes which can be considered self-sustained oscillations in a technical sense2). Evidence for this is given by the observation that, underconstant conditions, the rhythm continues a) undamped and b) with a frequency which deviates from that of the earth's rotation6). It is this deviation of the free-running 'ci...

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Dissociation of circadian and light inhibition of melatonin release through forced desynchronization in the rat.

Pineal melatonin release exhibits a circadian rhythm with a tight nocturnal pattern. Melatonin synthesis is regulated by the master circadian clock within the hypothalamic suprachiasmatic nucleus (SCN) and is also directly inhibited by light. The SCN is necessary for both circadian regulation and light inhibition of melatonin synthesis and thus it has been difficult to isolate these two regulat...

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Adverse effects of chronic circadian desynchronization in animals in a "challenging" environment.

Continuous disruption of circadian rhythms, as seen in human shift workers, has been associated with the development of a number of adverse mental and physiological conditions. However, scientific evidence linking circadian disruption to overall health, particularly in animal models, is not well documented. In this study, we have demonstrated that exposing C57BL/6J mice to 12-h phase shifts eve...

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Transient circadian internal desynchronization after light-dark phase shift in monkeys.

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ژورنال

عنوان ژورنال: Interface Focus

سال: 2010

ISSN: 2042-8898,2042-8901

DOI: 10.1098/rsfs.2010.0002